Mahesh A. Vibhute
Escherichia coli Bacterium. Illustration by David S. Goodsell
Researcher, erudite, Empiricist with a love for interdisciplinary action.
Background in synthetic biology, microfluidics and physical chemistry
bio
I am currently working as a postdoctoral researcher at TU Dortmund, The focus of my current projects is on establishing platforms for in vivo RNA replication and ssDNA production.
Prior to this, during my PhD, I worked on microfluidics and cytomimetic liposomes to study the physical biology of cells.
experience
01
functional rna replication
Self-replicating RNA, bacteriophages, directed evolution of RNA replicons, RNA-seq
02
in vivo ssdna synthesis
Expression of functional ssDNA such as aptamer and DNAzymes in vivo using bacterial retron systems
03
microfluidics
Cytomimetic liposome formation, Cell free gene expression, microfabrication
Cells are the most advanced chemical reactors on this planet. over the course of billions of years of evolution, they have become incredibly context specific and functional. If we ever hope to achieve proficiency in working with cells, we need robust, reproducible, and detailed experimental knowledge.
Escherichia coli Bacterium. Illustration by David S. Goodsell